Narcolepsy and Cataplexy
نویسنده
چکیده
After hearing the punch line of the joke, the teenager falls to the floor, almost as if actually punched. She remains there, completely unable to move. She hears her parents reassure her friends that they need not worry about her because she will be all right in a few minutes. She is embarrassed and frustrated as the episode continues, and her friends begin to leave. They bid her goodbye, but she is unable to respond. Although she cannot talk or move, she is otherwise in a state of high alertness, feeling, hearing and remembering everything that is going on around her. The episode lasts for five minutes, longer than her typical cataplexies--which often last only seconds--but shorter than her longest episode, which lasted 25 minutes. Then it ends, almost as abruptly as it began. She gets up from the floor, and her everyday life resumes.
منابع مشابه
Clinical and Polysomnographic Comparison between Narcolepsy without Cataplexy and Idiopathic Hypersomnia
Many patients report symptoms of hypersomnia with mostly excessive daytime sleepiness. According to the second edition of the International Classification of Sleep Disorders (ICSD2), hypersomnias of central origin are categorized as narcolepsy and idiopathic hypersomnia (IH).1 And narcolepsy can be divided into two categories based on the existence of cataplexy as narcolepsy with cataplexy (NTC...
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BACKGROUND Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy. However, the mechanism responsible for alteration of the hypocretin system in narcolepsy-cataplexy and its relevance to other central hypersomnias remain unknown. Here we studied whether central hypersomn...
متن کاملEtiopathogenesis and neurobiology of narcolepsy: a review.
Narcolepsy is a chronic lifelong sleep disorder and it often leaves a debilitating effect on the quality of life of the sufferer. This disorder is characterized by a tetrad of excessive daytime sleepiness, cataplexy (brief loss of muscle tone following strong emotion), hypnogogic hallucinations and sleep paralysis. There are two distinct subgroups of Narcolepsy: Narcolepsy with cataplexy and Na...
متن کاملPredictors of Hypocretin Deficiency in Narcolepsy without Cataplexy
1247 Hypocretin Deficiency in Narcolepsy Without Cataplexy—Andlauer et al INTRODUCTION Narcolepsy without cataplexy is a complex, heterogeneous disorder.1,2 Until recently, most narcolepsy studies have focused on narcolepsy with cataplexy, an etiologically homogenous disorder tightly associated with hypocretin deficiency and HLADQB1*06:02 positivity.3,4 Hypocretin deficiency can be tested by me...
متن کاملNarcolepsy and Cataplexy
Epidemiology [3] Prevalence is estimated as 25 per 100,000 in Caucasian populations. [4] Age of onset is typically around adolescence. A smaller number of cases presents at around 35 years. Less than 5% of narcolepsy with cataplexy occurs in children. One study found that it was often linked to complex movement disorders. [5] It is possible that incidence statistics would increase if diagnostic...
متن کاملHypocretin deficiency develops during onset of human narcolepsy with cataplexy.
STUDY OBJECTIVES Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. SETTING Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. PATIENT AND RESULTS Two weeks after his second Pandemrix-vacc...
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